于瑞涛 副研究员







于瑞涛,1979年2月生,博士,副研究员,硕士生导师,青海省自然科学与工程技术学科带头人,青海省 “高端创新人才千人计划”培养拔尖人才。2005年毕业于内蒙古科技大学生物科学专业, 2010年毕业于中科院西北高原生物研究所获得博士学位,主要从事青藏高原特色生物资源药效物质基础、活性筛选、作用机制及纳米载体药物相关研究。作为项目负责人主持或完成的项目14项。发表论文90篇,其中SCI收录论文50篇。获得授权专利44件,第一发明人授权26件;获得青海省科技成果12项,第一完成人3项。2014年度,2018年度在英国圣安德鲁斯大学访问学者。

1.Jing-Ya Cao, Zhi-Yao Wang , Alan J. Stewart , Qi Dong, Ye Zhao , Li-Juan Mei, Yan-duo Tao*, and Rui-Tao Yu*, Five new diarylbutyrolactones and sesquilignans from Saussurea medusa and their inhibitory effects on LPS-induced NO production. Planta Medica, 2023, 10.1055/a-1956-7829
2.Jing-Ya Cao , Zhi-Yao Wang , Qi Dong, Xiu Wang , Rui-Tao Yu* , Yan-Duo Tao *,Saussurenoids A-G, seven new sesquiterpenoids from Saussurea medusa Maxim.Tetrahedron 120 (2022) 132850
3.Jing-Ya Cao, Qi Dong, Zhi-Yao Wang, Ye Zhao , Yu Ren, Chang Liu, Jun Dang, Rui-Tao Yu *, Yan-Duo Tao*, Arylnaphthalide lignans from Saussurea medusa and their anti-inflammatory activities,Arabian Journal of Chemistry (2022) 15, 104155
4.Jing-Ya Cao , Li-Juan Mei, Nan Wu, Rui-Tao Yu* , Yan-Duo Tao *,Terpenoids from the whole plants of Saussurea medusa maxim. And their chemotaxonomic significance,Biochemical Systematics and Ecology 105 (2022) 104511
5. Jing-Ya Cao, Qi Dong, Zhi-Yao Wang, Li-Juan Mei, Yan-Duo Tao,* and Rui-Tao Yu*,Three Pairs of Novel Enantiomeric 8-O-4’ Type Neolignans from Saussurea medusa and Their Anti-inflammatory Effects In Vitro. Int. J. Mol. Sci. 2022, 23, 14062.
6.Jing-Ya Cao, Qi Dong, Zhi-Yao Wang, Ye Zhao, Yu Ren, Li-Juan Mei, Yan-duo Tao* & Rui-Tao Yu*, Megastigmane sesquiterpenoids from Saussurea medusa and their anti-inflammatory activities. Natural Product Research, DOI: 10.1080/14786419.2022.2146689
7.Jing-Ya Cao, Li-Juan Mei, Yanduo Tao*, Rui-Tao Yu*, NITROGENOUS CONSTITUENTS FROM Saussurea medusa. Chemistry of Natural Compounds, 2023, 59(3):616-618
8.Xiu Wang and Ruitao Yu* ,CHEMICAL COMPOSITIONS OF Lepidium latifolium L. Chemistry of Natural Compounds, 2023, In press.
9.Nan Wu and Ruitao Yu*, Chemical Constituents of Saussurea medusa Maxim. Chemistry of Natural Compounds, 2023, 59(3):546-548
10.Fang Wang , Xiongwei Qi , Jiahong Geng , Xiaoyan Liu , Dong Li , Hui Zhang*, Peng Zhang , Xiaolei He ,Baowei Li, Zhijia Li , Ruitao Yu*, Xiaoying Yang , Guangshuo Wang*, Template-free construction of hollow mesoporous Fe3O4 nanospheres as controlled drug delivery with enhanced drug loading capacity. Journal of Molecular Liquids. 2022, 118000
11.Juanhua Chai, Yingying Ma, Tonglai Guo, Ying He, Guangshuo Wang* , Fangfang Si, Jiahong Geng, Xiongwei Qi, Guoqing Chang*, Zhigang Ren, Ruitao Yu* , Liye Song, Dong Li. Assembled Fe3O4 nanoparticles on Zn–Al LDH nanosheets as a biocompatible drug delivery vehicle for pH-responsive drug release and enhanced anticancer activity. Applied Clay Science 228 (2022) 106630
12.Xiu Wang , Yupei Zhang, Nan Wu, Jingya Cao, Yanduo Tao and Ruitao Yu*. A method to separate two main antioxidants from Lepidium latifolium L. extracts using online medium pressure chromatography tower and two-dimensional inversion/hydrophobic interaction chromatography based on online HPLC-DPPH assay. Separations, 2021, 8, 238:1-10. https://doi.org/10.3390/separations8120238
13.Nan WU, Yanfang liu, Xinmiao Liang, Lijuan Mei, Yanduo Tao*, Ruitao YU*. Phytochemical and chemotaxonomic study on Saussurea medusa Maxim. (Compositae). Biochemical Systematics and Ecology. 93(2020)104171
14.Yupei Zhang, XiuWang, Sirong Jiang, Weidong Wang, Xiu Wang, Xiaoke Wu, Nan Wu, Yanduo Tao and Ruitao Yu*,CHEMICAL CONSTITUENTS OF Lepidium latifolium. Chemistry of Natural Compound, 2021, 57(4):767-769
15.Ma Z-Hong, Yu R-Tao*, Song J-Ming*, Facile synthesis of Pr-doped In2O3 nanoparticles and their high gas sensing performance for ethanol, Sensors and Actuators: B. Chemical,305 (2020)127377.
16.Ruixue YU, Ruitao YU*,Zhong LIU*. Inhibition of Two Gastric Cancer Cell Lines Induced By Fucoxanthin Involves Downregulation of Mcl-1 and STAT3, Human Cell, 2018,31:50-63.
17.Huaixiu Wen, Bowen Tang, Alan J. Stewart, Yanduo Tao, Yun Shao, Yulei Cui, Huilan Yue, Jinjin Pei, Zenggen Liu, Lijuan Mei, Ruitao Yu*, and Lei Jiang*, Erythritol Attenuates Postprandial Blood Glucose by Inhibiting -Glucosidase, J. Agric. Food Chem,2018, 66(6):1401-1407.
18.Guangshuo Wang ,Jiahong Geng, Xiongwei Qi , Tianxiang Du , Yingzhe Zeng , Ruitao Yu*, Mingwei Yuan, Hesong Peng. , Haibin Li. , Chao Chen* . Rheological performances and enhanced sedimentation stability of mesoporous Fe3O4 nanospheres in magnetorheological fluid. Journal of Molecular Liquids 336 (2021) 116389
19.Ruitao Yu, Zhong Liu, Ruixue Yu, Yun Shao, Lijuan Mei, Yanduo Tao*. Distribution of arctigenin in different organs of Saussurea medusa Maxim. from Qinghai-Tibetan plateau. Journal of medicinal plants research,2012,6(3): 361-365
20.Zhimin Shi, Yingzhe Zeng, Xin Chen, Fei Zhou, Liyun Zheng, GuangshuoWang, Jie Gao, Yingying Ma, Lianhong Zheng, Bin Fu, Ruitao Yu*.Mesoporous superparamagnetic cobalt ferrite nanoclusters: synthesis, characterization and application in drug delivery. Journal of Magnetism and Magnetic Materials.498 (2020)166222
21.HuiZhang, JianchaoWang, YingzheZeng, GuangshuoWang*, ShuaiHan, ZhitangYang, BaoweiLi , XiaominWang, JieGao, LiyunZheng, XiaoyanLiu, ZhongchaoHuo, RuitaoYu*, Leucine-coated cobalt ferrite nanoparticles: Synthesis, characterization and potential biomedical applications for drug delivery.Physics Letters A. 384 (2020) 126600.
22.Ruitao Yu, Ruixue Yu, Xingwang Zhang, Dynamic Microwave-Assisted Extraction of Arctigenin from Saussurea medusa Maxim., Chromatographia, 2010, 71, 335–339.
23.Ruitao Yu, Zhong Liu, Yanduo Tao, et al. A simple method for isolation and structural identification of arctigenin from Saussurea Medusa Maxim. by preparation chromatography and single crystal X-ray diffraction. Journal of medicinal plants research.2011,5(6): 979-983.
24.Ruixue Yu, Lei Jiang, Lijuan Mei, Yanduo Tao, Ruitao Yu*. Anti-inflammatory effects of alcohol extract from Saussurea medusa Maxim against lipopolysaccharides-induced acute lung injury mice. International Journal of Clinical and Experimental Medicine Research (IJCEMR), 2019, 3(4), 112-118.
25.S.-L. Huang, R.-T. Yu, J. Gong, Y. Feng, Y.-L.Dai, F. Hu, Y.-H. Hu, Y.-D. Tao*, Y. Leng*. Arctigenin, a natural compound, activates AMP-activated protein kinase via inhibition of mitochondria complex I and ameliorates metabolic disorders in ob/ob mice, Diabetologia, 2012, 55:1469–1481.
26.Amelie I. S. Sobczak, Kondwani G. H. Katundu, Fladia A. Phoenix,Siavash Khazaipoul, Ruitao Yu, Fanuel Lampiao, Fiona Stefanowicz,Claudia A. Blindauer, Samantha J. Pitt, Terry K. Smith, Ramzi A. Ajjan and Alan J. Stewart*, Albumin-mediated alteration of plasma zinc speciation by fatty acids modulates blood clotting in type-2 diabetes. Chemical Science. 2021, 12, 4079-4093
27.AIS Sobczak, O. Kassaar, S. Khazaipoul, R. Yu, R. Ajjan, CA. Blindauer, SJ. Pitt,AJ. Stewart1 Regulation of coagulation by zinc: characterisation of zinc-dependent heparin neutralisation by fibrinogen and histidine-rich-glycoprotein, CARDIOVASCULAR RESEARCH, 2018
28.Cui Yulei, Yue Huilan, Yu Ruitao, Wen Huaixiu, Mei Lijuan*, Tao Yanduo*, PHYTOCHEMICAL CONSTITUENTS FROM Arenaria kansuensis , Chemistry of Natural Compounds.2019,55(3):557–559
29.Minxia Fan, Lei Jiang, Ruitao Yu, Jianqiang Zhao,Xiang Yuan, Weidong Wang,and Lijuan Mei* .CHEMICAL CONSTITUENTS OF THE LEAVES OF Lycium barbarum. Chemistry of Natural Compounds, 54(6), November, 2018:1154-1156.
30.WeidongWang,LijinJiao,YanduoTao,YunShao,QilanWang,RuitaoYu,LijuanMei,JunDang,On-line HPLC-DPPH bioactivity-guided assay for isolated of antioxidative phenylpropanoids from Qinghai-Tibet Plateau medicinal plant Lancea tibetica Journal of Chromatography B. 2019 (1106–1107), Pages 1-10
31.YuleiCui, LeiJiang, RuitaoYu, YunShao,LijuanMei,YanduoTao. -carboline alkaloids attenuate bleomycin induced pulmonary fibrosis in mice through inhibiting NF-kb/p65 phosphorylation and epithelial-mesenchymal transition. Journal of Ethnopharmacology. 2019,243:1-9
32.Rong Wang, Yanfang Liu, Han Zhou, Yue Chen, Jixia Wang, Xiuli Zhang, Ruitao Yu, Xinmiao Liang*, Integration of micro-fractionation, high-performance liquid chromatography-ultraviolet detector-charged aerosol detector-mass spectrometry analysis and cellular dynamic mass redistribution assay to accelerate alkaloid drug discovery. Journal of Chromatography A. 1616(2020)460799
33.Yuan Xiang, Zhao Jing, Wang Haixia, Yu Ruitao, Wen Huaixiu, Liu Zenggen, Mei Lijuan, Wang Yiping. Tao* Yanduo. Antiproliferative Activity of Phenylpropanoids Isolated from Lagotis brevituba Maxim, Phytotherapy Research,2017,31(10) :1509-1520
34.Blindauer, CA , Khazaipoul, S , Yu, R & Stewart, AJ*. ' Fatty acid-mediated inhibition of metal binding to the multi-metal site on serum albumin: implications for cardiovascular disease ' Current Topics in Medicinal Chemistry,2016,16:3021-3032
35. Lei Jiang, Huaixiu Wen, Yun Shao, Ruitao Yu, Zenggen Liu,Shuo Wang,Qilan Wang,Xiaohui Zhao,Peng Zhang,Yanduo Tao*,Lijuan Mei*, Novel Diketopiperazine Dihydroorotate Dehydrogenase Inhibitors Purified from Traditional Tibetan Animal Medicine Osteon Myospalacem Baileyi ,Chemical Biology & Drug Design, 2015,86(4):626-636